About Us

HLAProtein.com was developed by Pure Protein, L.L.C and aims to provide researchers worldwide with best in class HLA protein reagents and testing services. Pure Protein was founded on the proprietary technologies of William Hildebrand, Ph.D. and is a portfolio company of life sciences technology management firm Emergent Technologies, Inc.

Words from the Director

Good research begins with superior reagents. We at HLAProtein understand that choosing a reagent provider is a difficult decision, and we are honored to be one of your considerations.

For over twenty years, we have built a reputation as a reliable provider of HLA proteins and applications. Using our extensive inventory of HLA reagents, we’ve created a diverse platform spanning from transplant diagnostics to immunotherapy development. Through HLAProtein, our customers not only excel in their experimental endeavors but are better prepared for the challenges ahead in the world of HLA.

We strive continuously to expand our reagent panels and offered services, making daily improvements to our product platforms and pipelines. We have always put our clients’ needs first to ensure that they reach their scientific goals. At HLAProtein, we see ourselves as more than just a company, we are your ally in scientific discovery. It is our intention to cultivate a warm, supportive, and diverse environment that will foster your personal or institutional growth.

We believe our efforts have produced an outstanding service portfolio, a strong vision, and innovative tools. The future of HLA is bright, and we are looking forward to welcoming you as our customer or collaborator.

Rico Buchli, PhD

Director of Research and Development
Vice President of Products and Services

Our Team

Pure Protein’s Scientific Team is comprised of leading experts with extensive knowledge in HLA research. With over 100 years of cumulative experience, the Company has developed a portfolio of proprietary technologies and methodologies that aim to support researchers across the world in HLA immunology. From soluble HLA manufacturing and diagnostics development to peptide binding and epitope discovery, our team looks forward to working with our customers and collaborators.

HLAprotein Team


Pure Protein is a biotechnology company focused on the development and commercialization of proprietary technologies related to the human leukocyte antigen (HLA) system. After over 20 years of developing these technologies, Pure Protein launched the HLAProtein.com website in 2020 to supply academic and commercial research groups with best in class, proprietary HLA protein reagents and testing services. HLAProtein.com now provides the world’s largest selection of single specificity, naturally folded, glycosylated soluble HLA proteins and HLA peptide binding services.

sHLA Class I proteins
sHLA Class II proteins
Years of research
Thomas Harlan, CEO of Emergent Technologies

Thomas Harlan, CEO, Emergent Technologies, Inc.

Pure Protein, independently and in concert with worldwide collaborators, aims to bring novel therapies, diagnostics, and research tools to clinicians, vaccine designers and researchers across an expansive variety of fields including transplantation, oncology, autoimmunity and infectious diseases.


Meet Rico

Dr. Rico Buchli
Biochemistry, Molecular Biology & Immunology
Director of Research
Vice President of Products and Services

Dr. Buchli joined Pure Protein L.L.C. in 2001 and is currently applying his expertise in Immunology and Biochemistry as the Director of Research and as the Vice President of Products and Services. His work is essential to Pure Protein’s ongoing development of soluble HLA technology. The study of HLA has grown increasingly important in the fields of infectious disease, cancer, and transplant rejection. Dr. Buchli possesses decades of experience with HLA and hopes to standardize its use across these fields.

Appointed by the Swiss Ministry of Foreign Affairs with the approval of the U.S. Department of State, Dr. Buchli also serves as the Honorary Consul of Switzerland. He is a member of multiple committees, including the Oklahoma Governor’s International Team (OKGIT) and the Advisory Committee of the U.S. Global Leadership Coalition.

Dr. Buchli received his Ph.D. in Biochemistry from the University of Basel, Switzerland in 1996 and served as a Postdoctoral Researcher at UC Davis until 2001 before accepting a Research Assistant Professor position at the University of Oklahoma, Health Science Center. As a recognized authority in his field, Dr. Buchli has been published extensively by some of the leading international, peer-reviewed journals, including the Journal of Biological Chemistry, Journal of Biochemistry, Journal of Cellular Biochemistry, Molecular and Cellular Biochemistry, Cancer Letters, Journal of Immunology, as well as others. He is the recipient of the Albert M. Kligman Award in Dermatology and The Journal Record’s On the Brink Innovator Award. Dr. Buchli is also a co-inventor on multiple International and U.S. patents.

Meet Fred

Dr. Ying-Yu Fred Wu
Microbiology & Immunology
Manufacturing Manager

Dr. Wu joined Pure Protein L.L.C. in 2017. As an Immunologist with more than 20 years of experience, he is currently applying his broad technical expertise to the manufacturing of HLA proteins at small, medium, and large scale. In addition to being a production and purification expert, he is also involved in antibody and HLA matrix coupling; the conjugation of HLA with biotin and fluorophores; engineering of HLA peptide complexes; and T-cell peptide epitope validation and screening. Being responsible for sHLA quality control, Dr. Wu employs many immunoassays to confirm the integrity of HLA protein products. Dr. Wu also has extensive experience in flow cytometry techniques currently applied in the development of tetramer products for B cell and T cell detection.

Dr. Wu received his Ph.D. in Microbiology and Immunology from the National Yang-Ming University of Taipei, Taiwan in 2005. He served as a postdoctoral fellow at Academia Sinica in Taiwan, and at Beth Israel Deaconess Medical Center in Boston until 2009. After four years of service, he accepted a research position at Oklahoma Medical Research Foundation (OMRF) in Oklahoma City before joining Pure Protein. Dr. Wu has published many papers in high-profile international journals including the Journal of Immunology, Journal of Experimental Medicine, Plos One, Journal of Biological Chemistry, and others.

Meet Leslie

Leslie Wilmot, A.A.S.
Lab Manager

Leslie joined Pure Protein L.L.C. in 2016 as a Laboratory Technician and was promoted to Laboratory Manager in 2021. She oversees order processing, shipping, documentation, inventory management, and customer service. She graduated from Oklahoma City Community College earning an A.A.S. in Biotechnology in 2013 and an A.A. in Psychology in 2014. She is currently attending Oklahoma State University and will graduate in 2024 earning a B.S.B.A. in Management Information Systems with a concentration in Data Science.

Meet Jacob

Jacob Collard, B.S.

Jacob joined Pure Protein L.L.C. in 2016 and has served since as its primary quality control technician. His responsibilities are far reaching, providing expertise in a variety of assay formats including ELISA, Luminex and Chip platforms. He maintains standard operating procedures throughout all aspects of quality control, performing various product upgrades including biotinylation of HLA and tetramer re-purification. Jacob is also responsible for peptide binding validation and screening services offered by the Pure Protein Lab. Jacob earned a B.S. in Biology at Oklahoma Baptist University in 2014.

Meet Sean

Sean Osborn, B.S.
Biomedical Science
Senior Laboratory Technician | HLA Typing Specialist

Sean Osborn is a Senior Laboratory Technician at Pure Protein L.L.C., where he specializes in DNA sequencing for quality assurance and patient evaluation. With extensive experience in biomedical science, Sean previously worked in Dr. William Hildebrand's laboratory, conducting HLA sequence-based typing to facilitate transplantation procedures. His meticulous approach and commitment to precision have consistently ensured successful matches between donors and recipients.

Sean's academic journey includes earning an Associate of Applied Science in Biotechnology from Oklahoma City Community College in 2006. He advanced his education by graduating Magna Cum Laude with a Bachelor of Science in Biomedical Science from the University of Central Oklahoma in December 2023. Committed to staying updated with the latest technologies, Sean actively pursues continuing education to remain at the forefront of his field.

With a proven track record of excellence and a dedication to advancing scientific knowledge, Sean continues to make significant contributions to the biomedical science community. His expertise and passion for precision make him an invaluable asset in ensuring the highest standards of quality and accuracy in laboratory operations.


Join our Team

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