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Illuminate the intricacies of the immune response with soluble HLA


Soluble HLA Technology

Pure Protein’s pioneering approach produces soluble forms of HLA Class I and II proteins (sHLA). These molecules support the development of diagnostic and therapeutic applications by creating properly configured and reproducible native HLA proteins in an industrialized and standardized process. This proprietary technology delivers naturally glycosylated, endogenously loaded, natively folded, recombinant molecules lacking transmembrane and cytosolic domains, that are synthesized in mammalian cells and purified using affinity chromatography.

sHLA Class I proteins
sHLA Class II proteins
Years of research
3D molecular structure of an HLA protein
3D molecular structure of an HLA protein

Choose from a range of HLA products and services

Soluble HLA Proteins Class I

Mammalian produced, endogenously loaded, and naturally folded recombinant soluble HLA Class I proteins

Soluble HLA Proteins Class II

Mammalian produced, zipper stabilized, endogenously loaded, and naturally folded recombinant soluble HLA Class II proteins

Peptide Validation and Screening Services

Competition-based HLA peptide binding assays for the validation and screening of putative T cell epitopes

Pure protein offices

About us

Pure Protein, L.L.C. (Pure Protein) is an HLA company that has developed comprehensive analytical capabilities in the field of human leukocyte antigen (HLA) immunology and an approach to produce soluble forms of the HLA molecule (sHLA). Pure Protein provides technology and expertise to advance novel therapies and diagnostic tools across a wide range of applications, covering areas of antibody mediated rejection in transplantation and peptide epitope based therapeutics in oncology, autoimmunity, and infectious diseases.


2023 BIO International Convention


HLAprotein is attending the 2023 BIO International Convention!

  • "HLAprotein.com is excited to exhibit at Booth 1149 at 2023 BIO International Convention in Boston, MA."

BIO is the world’s largest trade association representing biotechnology companies, academic institutions, state biotechnology centers, and related organizations across the United States and in more than 30 other nations. BIO’s annual convention provides HLAprotein the opportunity to meet with new potential partners and connect on existing relationships to explore collaboration opportunities.

Hope to see you there!

Schedule a meeting with Pure Protein’s Business Development and Scientific Leadership team:

June 5-8, 2023 | Boston, MA

Meet Us at the OKBio Booth 1149!


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