Reliable HLA Products and Services
When your research demands unique and qualified HLA reagents or services, turn to our expert scientists and quality assurance team to receive solutions tailored to bring you faster and more cost-effective success. We deliver high purity reagents and improved peptide binding services that produce consistent and repeatable results.
Soluble HLA Class I and II Proteins
HLA genes are highly polymorphic, representing the most genetically variable gene region by encoding thousands of different alleles. We offer a wide selection of single-specificity HLA proteins with broad population coverage. Since sHLA molecules lack the transmembrane portion, these proteins are not retained on the cell surface but are readily secreted, allowing economic production and purification and eliminating the inherent problems of detergent cell lysates.
Soluble HLA proteins are well characterized, proven to present native, antigenic epitopes recognized by specific antibodies, demonstrate high stability and integrity of their structures over time, are adaptable for individual needs, and are compliable on many application platforms.
Peptide Epitope Validation
Peptide Epitope Screening
T cell Epitope Mapping
Soluble HLA Technology
Our pioneering approach produces soluble forms of HLA Class I and II proteins (sHLA). This proprietary technology delivers naturally glycosylated, endogenously loaded, natively folded, recombinant molecules lacking transmembrane and cytosolic domains, that are synthesized in mammalian cells and purified using affinity chromatography.
With over twenty years of research, our company has developed hundreds of Class I and Class II sHLA proteins representing all major classes including A, B, C, DR, DQ and DP that can be used for critical research in the development of diagnostic and therapeutic applications in the field of transplant rejection and immunotherapy.