A unique non-classical MHC molecule at the center for studies in immune tolerance, cancer, transplantation, and reproductive immunology.
HLA-G
Our soluble HLA-G proteins offer authentic structural and functional integrity for use in receptor binding studies, assay development, and immunological research across oncology, transplantation, and infectious disease. Learn more about HLA.
HLA-G Product Portfolio
High-Quality HLA-G Reagents for Translational Research
Human Leukocyte Antigen-G (HLA-G) promotes immune tolerance in reproduction, transplantation, cancer, autoimmunity, and infection. Many commercial HLA-G reagents lack native glycosylation, proper folding, and physiologic peptide loading, limiting their translational relevance.
HLA Protein Technologies offers a proprietary platform producing fully peptide-loaded, β2-microglobulin–complexed HLA-G5 [G*01:01] reagents. Available as monomers, tetramers, multimers, and biotinylated or fluorescent complexes, these versatile tools support drug discovery, high-throughput diagnostics, and next-generation immune therapeutics.
Unlock immune insights with fully native, ready-to-use HLA-G reagents.
Select from a range of convenient modalities
Key Applications of Soluble HLA-G
Our recombinant HLA-G molecules integrate seamlessly into diverse immunological workflows. They support quantitative and cell-based assays, kinetic binding studies, and immunotherapeutic screening with high biological fidelity. From hybridoma and display technologies to precise peptide and epitope mapping, these reagents deliver reliable tools for investigating immune regulation, validating receptor interactions, and accelerating translational immunology research.
Versatile HLA-G reagents powering assays, screening, and translational immunology research.
1.
Quantitative Immunoassays
2.
Cell-based Functional Assays
3.
Biophysical and Binding Kinetics
4.
Immunotherapeutic Discovery and Screening
5.
Hybridoma and Display Technologies
6.
Peptide and Epitope Mapping
Resources
SOLUBLE HLA TECHNOLOGY
Learn more about our sHLA Technology and how it can improve the quality and speed of your science
HLA APPLICATIONS
Explore the landscape of HLA applications in the fields of transplantation, autoimmunity, cancer and infectious diseases and find new ways to improve your research
SOLUBLE HLA PUBLICATIONS
Read more about our publications and discover new resources and ideas to support your endeavors
Frequently Asked Questions
What is sHLA Technology?
Soluble HLA Technology is referred to the process of transforming membrane-bound HLA molecules into soluble and secretable proteins without changing their antigenicity and peptide load through molecular cloning and expression in a mammalian system.
What is the most popular Class I sHLA used?
Because of its high population occurrence, sHLA-A*02:01 is our most popular allele.
How do I store sHLA molecules?
Soluble HLA is preferably stored at 4˚C. We recommend using styrofoam containers to prevent temperature fluctuations.
Related Products & Services
HLA-B Proteins
Select from a pool of over 65 HLA-B alleles to drive your immunological research to identify antibody immune responses or visualize antigen-specific immune cells
HLA-A Proteins
Choose from more than 35 HLA-A alleles to detect, profile, or monitor antigen-specific immune responses from antibodies to immune cell populations
Peptide Validation and Screening Services
Competition-based HLA peptide binding assays for the validation and screening of putative T cell epitopes
